This project aims to produce the bioinformatics resources needed by BBMRI-NL participating biobanks and rainbow and complementation projects, most notably in the context of Genoom van Nederland:
- Sequence data management, QC and analysis pipelines to produce and share a Dutch catalog of variants.
- GWAS data management, QC and imputation to produce a Dutch GWAS control cohort
- Dutch (inter)national biobank catalog and data exchange formats
- Scalable and easy to maintain software and web access tools underlying 1-3.
All these resources will be made publically available both as centralized, secured, web accessible national services, i.e. central hubs assembled in partnership to support the rainbow projects, as well as downloadable and customizable ‘tools-in a-box’ meant for local installation by biobanks and their local projects (local hubs). This project will develop in parallel the scientific, professional and physical infrastructures needed to effectively communicate expertise, procedures and tools between all Dutch biobanks as well as the provision of bioinformatics experts building on the infrastructure organized in the Netherlands Bioinformatics Center (NBIC) BioAssist program. This group will work in coordination with the BBMRI-NL ethical-legal working group to develop a code of practice and guidelines for large scale harmonized data pooling and for the use of data from multiple biobanks.
See also http://www.bbmriwiki.nl/ where this whole project is managed.